引用本文:
陈启凡, 张慧东, 宫胜臣. 4-取代-2-氨基嘧啶衍生物的合成[J]. 应用化学,
2011, 28(4): 382-386.
doi:
10.3724/SP.J.1095.2011.00372
Citation: CHEN Qifan, ZHANG Huidong, GONG Shengchen. Synthesis of 4-Substituted-2-Amino-pyrimidines[J]. Chinese Journal of Applied Chemistry, 2011, 28(4): 382-386. doi: 10.3724/SP.J.1095.2011.00372
Citation: CHEN Qifan, ZHANG Huidong, GONG Shengchen. Synthesis of 4-Substituted-2-Amino-pyrimidines[J]. Chinese Journal of Applied Chemistry, 2011, 28(4): 382-386. doi: 10.3724/SP.J.1095.2011.00372
4-取代-2-氨基嘧啶衍生物的合成
English
Synthesis of 4-Substituted-2-Amino-pyrimidines
Abstract:
N,N-Dimethylformamide-dimethyl acetal(DMF-DMA) was refluxed with the corresponding aromatic or heterocyclic compounds to prepare the intermediates 3-(dimethylamino)-1-(substituted) prop-2-en-1-one with a yield of 71.2%~85.2%.By refluxing the obtained intermediates with guanidine hydrochloride in ethanol and in the presence of sodium ethoxide,fourteen 4-substituted-2-amino-pyrimidines were obtained in good yield of 66.6%~86.1%.All the products were confirmed by NMR,mass spectrometry,and elemental analysis.
-
Key words:
- substituted-amino-pyrimidines
- / synthesis
- / characterization
-
-
扫一扫看文章
计量
- PDF下载量: 0
- 文章访问数: 773
- HTML全文浏览量: 54
下载:
