引用本文:
安悦, 牟萍萍, 张英, 张婷, 吕建州, 陈欣. 取代-1H-吡唑-5-甲酸与取代噻二唑-2-氨的酰胺化合物的合成及生长素活性[J]. 应用化学,
2010, 27(6): 646-650.
doi:
10.3724/SP.J.1095.2010.90497
Citation: AN Yue, MU Ping-Ping, ZHANG Ying, ZHANG Ting, LV Jian-Zhou, CHEN Xin. Synthesis and Auxin Activities of Acylamides with Substituted-1H-pyrazole-5-formic Acid and Substituted Thiadiazole-2-ammonia[J]. Chinese Journal of Applied Chemistry, 2010, 27(6): 646-650. doi: 10.3724/SP.J.1095.2010.90497
Citation: AN Yue, MU Ping-Ping, ZHANG Ying, ZHANG Ting, LV Jian-Zhou, CHEN Xin. Synthesis and Auxin Activities of Acylamides with Substituted-1H-pyrazole-5-formic Acid and Substituted Thiadiazole-2-ammonia[J]. Chinese Journal of Applied Chemistry, 2010, 27(6): 646-650. doi: 10.3724/SP.J.1095.2010.90497
取代-1H-吡唑-5-甲酸与取代噻二唑-2-氨的酰胺化合物的合成及生长素活性
English
Synthesis and Auxin Activities of Acylamides with Substituted-1H-pyrazole-5-formic Acid and Substituted Thiadiazole-2-ammonia
Abstract:
Ethyl 3-(4-methoxy phenyl)-1H-pyrazole-5-carboxylate was synthesized by means of one-pot reaction method;and two kinds of pyrazole carboxylic acid were obtained through methylation at position 1,chlorination at position 4 and hydrolysis.Six 5-substituted-2-amino-1,3,4-thiadiazoles were obtained from substituted carboxylic acids and thiosemicarbazide using phosphorus acylchloride as the dehydrating agent.Pyrazole and 1,3,4-thiadiazole were connected together by amido bond and 12 new compounds were synthesized.The yield of the title compounds was up to 50%.All the new compounds were confirmed by means of elemental analysis,IR and 1H NMR spectroscopies.Their auxin activities are not high,and a few of them are antiblastic to wheat gemma.
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Key words:
- pyrazole
- / thiadiazole
- / synthesis
- / biological activity
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