Study on the Synthesis and Antitumor Activity of New Indolocarbazole Compounds

ZHAO Ling-Ling ZHAI Fu-Min XIE Ming-Chao QI Gang

Citation:  ZHAO Ling-Ling, ZHAI Fu-Min, XIE Ming-Chao, QI Gang. Study on the Synthesis and Antitumor Activity of New Indolocarbazole Compounds[J]. Chinese Journal of Structural Chemistry, 2016, 35(2): 205-211. doi: 10.14102/j.cnki.0254-5861.2011-0967 shu

Study on the Synthesis and Antitumor Activity of New Indolocarbazole Compounds

  • 基金项目:

    technology support project of Jiangsu Province (No. BY2015057-03) (No. BY2015057-03)

摘要: A series of new antitumor compounds having indolecarbazole structures were designed and synthesized. The methoxy substituted indolecarbazole parent nucleus, which was firstly synthesized, is condensed with bromine substituted amino acid methyl ester to produce the target compounds. The target compounds were performed with methylthiazolyldiphenyl-tetrazolium bromide (MTT) in vitro cytotoxin activity test and the results showed that compounds CZ-1, CZ-3 and CZ-6 have higher activity against human colon cancer (HT-29) and (HCT-8), hepatocellular carcinoma (Bel-7402), NSCLC (A549) and breast cancer (MCF-7) cells as compared to the positive control JDC-108.

English

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  • 收稿日期:  2015-09-02
  • 网络出版日期:  2015-12-01
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