Study on the Synthesis and Antitumor Activity of New Indolocarbazole Compounds
English
Study on the Synthesis and Antitumor Activity of New Indolocarbazole Compounds
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Key words:
- indolecarbazole
- / antitumor activity
- / cytotoxin activity
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[1]
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(2) Hoshino, S.; Zhang, L.; Awakawa, T.; Wakimoto, T.; Onaka, H.; Abe, I. Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and streptomyces cinnamoneus NBRC 13823. J. Antibiot. 2015, 68, 342-344.(2) Hoshino, S.; Zhang, L.; Awakawa, T.; Wakimoto, T.; Onaka, H.; Abe, I. Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and streptomyces cinnamoneus NBRC 13823. J. Antibiot. 2015, 68, 342-344.
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(3) Nakano, H.; Omura, S. Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine. J. Antibiot. 2009, 62, 17-26.(3) Nakano, H.; Omura, S. Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine. J. Antibiot. 2009, 62, 17-26.
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(4) Miller, J. J.; Browne, P. C.; Detwiller, C. Complexes of thrombin secreted platelet protein. Biochem. Biophys. Res. Commun. 1988, 151, 9-15.(4) Miller, J. J.; Browne, P. C.; Detwiller, C. Complexes of thrombin secreted platelet protein. Biochem. Biophys. Res. Commun. 1988, 151, 9-15.
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(5) Rodigues, P. E.; Belin, L.; Sancelme, M.; Prudhone, M.; Ollier, M.; Rapp, M.; Serere, D.; Riou, J.; Felbro, D.; Meyer, T. Structure-activity relationships in a series of substituted indolocarbazoles; Topoisomerase I and antitumoral and antimicrobial properties. J. Med. Chem. 1996, 39, 4471-4477.(5) Rodigues, P. E.; Belin, L.; Sancelme, M.; Prudhone, M.; Ollier, M.; Rapp, M.; Serere, D.; Riou, J.; Felbro, D.; Meyer, T. Structure-activity relationships in a series of substituted indolocarbazoles; Topoisomerase I and antitumoral and antimicrobial properties. J. Med. Chem. 1996, 39, 4471-4477.
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(6) Bally, C.; Qu, X.; Anizon, F.; Prudhomme, M.; Riou, J.; Chaires, J. B. Enhanced binding to DNA and Top I inhibitor, an analogue of the antitumor antibiotic rebeccamycin containing an amino suguar residue. Mol. Pharm. 1999, 55, 377-385.(6) Bally, C.; Qu, X.; Anizon, F.; Prudhomme, M.; Riou, J.; Chaires, J. B. Enhanced binding to DNA and Top I inhibitor, an analogue of the antitumor antibiotic rebeccamycin containing an amino suguar residue. Mol. Pharm. 1999, 55, 377-385.
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(7) Faul, B. H.; Winneroski, L. L.; Kumrich, C. A. Synthesis of rebeccamycin and 11-dechlororebeccamycin. J. Org. Chem. 1999, 64, 2465-2470.(7) Faul, B. H.; Winneroski, L. L.; Kumrich, C. A. Synthesis of rebeccamycin and 11-dechlororebeccamycin. J. Org. Chem. 1999, 64, 2465-2470.
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(8) Ohkubo, M.; Nishimura, T.; Jona, H.; Honma, T.; Morishima, H. Practical synthesis of indolopyrrolocarbazoles. Tetrahedron 1996, 52, 8099-8112.(8) Ohkubo, M.; Nishimura, T.; Jona, H.; Honma, T.; Morishima, H. Practical synthesis of indolopyrrolocarbazoles. Tetrahedron 1996, 52, 8099-8112.
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(9) Brockmann, T. W.; Tour, J. M. Synthesis of low-bandgap zwiterionic and planner conjugated pyrrole-derived polymers. Reversible optical absorption from the UV to the new-IR. J. Am. Chem. Soc. 1994, 116, 7435-7436.(9) Brockmann, T. W.; Tour, J. M. Synthesis of low-bandgap zwiterionic and planner conjugated pyrrole-derived polymers. Reversible optical absorption from the UV to the new-IR. J. Am. Chem. Soc. 1994, 116, 7435-7436.
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