Citation:
WANG Fang-Ming, BAO Dan, WANG Ming, LI Ming-Jun, CHEN Li-Zhuang, HAN Guang-Fan. Syntheses and Crystal Structures of Pyridyl Substituted Dibenzo [b,e]-[1,4]diazepin-1-one Derivatives[J]. Chinese Journal of Structural Chemistry,
2015, 34(2): 179-184.
doi:
10.14102/j.cnki.0254-5861.2011-0394
Syntheses and Crystal Structures of Pyridyl Substituted Dibenzo [b,e]-[1,4]diazepin-1-one Derivatives
摘要:
A new series of 11-pyridyl substituted dibenzo-diazepin-1-one derivatives 1 was synthesized by a two step cyclocondensation reaction. All the compounds were characterized by IR, MS, and 1H NMR. And crystals of 1a and 1b were obtained and determined by X-ray single-crystal diffraction. Crystal data of 1a: C48H52N6O7, monoclinic system, space group C2/c, a=28.39(4), b=9.275(12), c=16.84(2)Å, β=104.98(3)°, V=4284(10)Å3, Z=4, F(000)=1752, Dc=1.279 g/cm3, R=0.0603, and wR=0.1314. Crystal data of 1b: C24H21N3O, monoclinic system, space group P21/c, a=11.625(5), b=19.055(9), c=8.741(4)Å, β=95.547(6)°, V=1927.2(15)Å3, Z=4, F(000)=776, Dc=1.266 g/cm3, R=0.0494, and wR=0.1287.
English
Syntheses and Crystal Structures of Pyridyl Substituted Dibenzo [b,e]-[1,4]diazepin-1-one Derivatives
Abstract:
A new series of 11-pyridyl substituted dibenzo-diazepin-1-one derivatives 1 was synthesized by a two step cyclocondensation reaction. All the compounds were characterized by IR, MS, and 1H NMR. And crystals of 1a and 1b were obtained and determined by X-ray single-crystal diffraction. Crystal data of 1a: C48H52N6O7, monoclinic system, space group C2/c, a=28.39(4), b=9.275(12), c=16.84(2)Å, β=104.98(3)°, V=4284(10)Å3, Z=4, F(000)=1752, Dc=1.279 g/cm3, R=0.0603, and wR=0.1314. Crystal data of 1b: C24H21N3O, monoclinic system, space group P21/c, a=11.625(5), b=19.055(9), c=8.741(4)Å, β=95.547(6)°, V=1927.2(15)Å3, Z=4, F(000)=776, Dc=1.266 g/cm3, R=0.0494, and wR=0.1287.
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Key words:
- X-ray diffraction
- / crystal structure
- / benzodiazepine
- / synthesis
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