Citation:
Guo-liang Yue, Qian-ling Cui, Yu-xi Zhang, Er-jian Wang, Fei-peng Wu. THERMO-RESPONSIVE BLOCK COPOLYMERS BASED ON LINEAR-TYPE POLY(ETHYLENE GLYCOL): TUNABLE LCST WITHIN THE PHYSIOLOGICAL RANGE[J]. Chinese Journal of Polymer Science,
2012, 30(5): 770-776.
doi:
10.1007/s10118-012-1179-2
THERMO-RESPONSIVE BLOCK COPOLYMERS BASED ON LINEAR-TYPE POLY(ETHYLENE GLYCOL): TUNABLE LCST WITHIN THE PHYSIOLOGICAL RANGE
English
THERMO-RESPONSIVE BLOCK COPOLYMERS BASED ON LINEAR-TYPE POLY(ETHYLENE GLYCOL): TUNABLE LCST WITHIN THE PHYSIOLOGICAL RANGE
Abstract:
Thermo-responsive block copolymers poly(ethylene glycol)-block-poly(N-acryloyl-2,2-dimethyl-1,3-oxazolidine), PEG-b-PADMO, based on linear PEG were prepared via a versatile reversible addition-fragmentation chain transfer (RAFT) polymerization. PEG22 (Mw=1000) was used as the hydrophilic component, whose dehydration was the main driving force for the phase transition of these copolymers, as demonstrated by the 1H-NMR spectra. Their lower critical solution temperatures (LCSTs) could be tuned in the range of 20℃ to 35℃, by adjusting the degree of polymerization (DP) of PADMO between 14-27. Furthermore, a sharp phase transition at ca. 33℃, close to the physiological temperature with minimal hysteresis, was observed for the PEG22-b-PADMO14 copolymer. Moreover, excellent reversibility and reproducibility were displayed for the same copolymer over 10 cycles of repeated temperature change between 25℃ (below the LCST) and 40℃ (above the LCST).
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Key words:
- Thermo-responsive
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