Facile synthesis of benzimidazole bearing 2-pyridone derivatives as potential antimicrobial agents

Citation: N.C. Desai, N.R. Shihory, G.M. Kotadiya. Facile synthesis of benzimidazole bearing 2-pyridone derivatives as potential antimicrobial agents[J]. Chinese Chemical Letters, 2014, 25(2): 305-307. shu

Facile synthesis of benzimidazole bearing 2-pyridone derivatives as potential antimicrobial agents

通讯作者: N.C. Desai,

摘要: A series of benzimidazole bearing 2-pyridones 5a-k were synthesized and assessed in vitro for their activity as antimicrobial agents using the conventional broth dilution method. The results of the antimicrobial study revealed that compounds 5b, 5c, 5j and 5k exhibited substantial antibacterial activity while compound 5d emerged as amore potent antifungal agent compared to the standard drugs chloramphenicol and ketoconazole, respectively. It was observed that the presence of inductively electron withdrawing groups remarkably enhance the antibacterial activity of the newly synthesized compounds. Cytotoxicity studies suggested that none of the tested compounds exhibited any significant cytotoxic effects.

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