引用本文:
Peng SUN, Yang Hua YI, Ling LI, Min GUI, Hai Feng TANG, Da Zhi ZHANG, Shi Long ZHANG. 17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuria impatiens[J]. Chinese Chemical Letters,
2006, 17(11): 1454-1456.
Citation: Peng SUN, Yang Hua YI, Ling LI, Min GUI, Hai Feng TANG, Da Zhi ZHANG, Shi Long ZHANG. 17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuria impatiens[J]. Chinese Chemical Letters, 2006, 17(11): 1454-1456.
Citation: Peng SUN, Yang Hua YI, Ling LI, Min GUI, Hai Feng TANG, Da Zhi ZHANG, Shi Long ZHANG. 17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuria impatiens[J]. Chinese Chemical Letters, 2006, 17(11): 1454-1456.
17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuria impatiens
摘要:
A new sulfated triterpene glycoside named as 17-dehydroxyholothurin A 1 was isolated from the sea cucumber Holothuria impatiens. Its structure was elucidated on the basis of spectroscopic data (2D NMR and MS) and chemical evidence. Compound 1 showed cytotoxic activity against cancer cell lines MKN-28, MFC-7, KB, HL-60 and Hep G2 with IC50 values of 1.98, 4.53, 2.01, 4.69 and 2.80×10-6 mol/L, respectively.
English
17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuria impatiens
Abstract:
A new sulfated triterpene glycoside named as 17-dehydroxyholothurin A 1 was isolated from the sea cucumber Holothuria impatiens. Its structure was elucidated on the basis of spectroscopic data (2D NMR and MS) and chemical evidence. Compound 1 showed cytotoxic activity against cancer cell lines MKN-28, MFC-7, KB, HL-60 and Hep G2 with IC50 values of 1.98, 4.53, 2.01, 4.69 and 2.80×10-6 mol/L, respectively.
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Key words:
- Sea cucumber
- / Holothuria impatiens
- / 17-dehydroxyholothurin A
- / triterpene glycoside
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