引用本文:
Jun Bo WANG, Chun Hao YANG, Xue Ming YAN, Xi Han WU, Yu Yuan XIE. Novel Bone-targeted Agents for Treatment of Osteoporosis[J]. Chinese Chemical Letters,
2005, 16(7): 859-862.
Citation: Jun Bo WANG, Chun Hao YANG, Xue Ming YAN, Xi Han WU, Yu Yuan XIE. Novel Bone-targeted Agents for Treatment of Osteoporosis[J]. Chinese Chemical Letters, 2005, 16(7): 859-862.
Citation: Jun Bo WANG, Chun Hao YANG, Xue Ming YAN, Xi Han WU, Yu Yuan XIE. Novel Bone-targeted Agents for Treatment of Osteoporosis[J]. Chinese Chemical Letters, 2005, 16(7): 859-862.
Novel Bone-targeted Agents for Treatment of Osteoporosis
摘要:
The novel bone-targeted agents were designed and synthesized by the combination of raloxifene and bisphosphonates. The anti-osteoporosis effect was evaluated by bone mineral density (BMD) obtained from OVX mice in vivo. The results indicated that the compound 8, 9 not only prevented ovariectomy induced loss of bone but also enhanced BMD to 0.87% and 19.67% compared to Sham, respectively.
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关键词:
- Osteoporosis
- / bone-targeted
- / raloxifene
- / bisphosphonate
English
Novel Bone-targeted Agents for Treatment of Osteoporosis
Abstract:
The novel bone-targeted agents were designed and synthesized by the combination of raloxifene and bisphosphonates. The anti-osteoporosis effect was evaluated by bone mineral density (BMD) obtained from OVX mice in vivo. The results indicated that the compound 8, 9 not only prevented ovariectomy induced loss of bone but also enhanced BMD to 0.87% and 19.67% compared to Sham, respectively.
-
Key words:
- Osteoporosis
- / bone-targeted
- / raloxifene
- / bisphosphonate
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