引用本文:
Yu Zhen SHI, Zhi Chun CHEN, Na WANG, Qi WU, Xian Fu LIN. Lipase-catalyzed Regioselective Synthesis of Vinyl Ester Derivatives of Thiamphenicol:Novel Thiamphenicol Monomers for Preparation of Macromolecular Antibiotic[J]. Chinese Chemical Letters,
2005, 16(1): 45-48.
Citation: Yu Zhen SHI, Zhi Chun CHEN, Na WANG, Qi WU, Xian Fu LIN. Lipase-catalyzed Regioselective Synthesis of Vinyl Ester Derivatives of Thiamphenicol:Novel Thiamphenicol Monomers for Preparation of Macromolecular Antibiotic[J]. Chinese Chemical Letters, 2005, 16(1): 45-48.
Citation: Yu Zhen SHI, Zhi Chun CHEN, Na WANG, Qi WU, Xian Fu LIN. Lipase-catalyzed Regioselective Synthesis of Vinyl Ester Derivatives of Thiamphenicol:Novel Thiamphenicol Monomers for Preparation of Macromolecular Antibiotic[J]. Chinese Chemical Letters, 2005, 16(1): 45-48.
Lipase-catalyzed Regioselective Synthesis of Vinyl Ester Derivatives of Thiamphenicol:Novel Thiamphenicol Monomers for Preparation of Macromolecular Antibiotic
摘要:
Three polymerizable vinyl thiamphenicol esters with different acyl donor carbon chain length (C4, C6, C10) were regioselectivly synthesized by Lipozyme® (immobilized from mucor miehei) in acetone at 50℃ for 12 h to give 73%, 81%, 63% yield, respectively. The products were valuable monomers for preparation of macromolecular antibiotic.
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关键词:
- Thiamphenicol
- / vinyl ester
- / transesterification
- / regioselectivity
- / monomer.
English
Lipase-catalyzed Regioselective Synthesis of Vinyl Ester Derivatives of Thiamphenicol:Novel Thiamphenicol Monomers for Preparation of Macromolecular Antibiotic
Abstract:
Three polymerizable vinyl thiamphenicol esters with different acyl donor carbon chain length (C4, C6, C10) were regioselectivly synthesized by Lipozyme® (immobilized from mucor miehei) in acetone at 50℃ for 12 h to give 73%, 81%, 63% yield, respectively. The products were valuable monomers for preparation of macromolecular antibiotic.
-
Key words:
- Thiamphenicol
- / vinyl ester
- / transesterification
- / regioselectivity
- / monomer.
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