引用本文:
Jia Cheng NING, Shu MAO, Ye Di GUAN. Asymmetric Synthesis of α-Substituted-γ-butyrolactone Empolying Prolinol Type of Auxiliaries[J]. Chinese Chemical Letters,
2005, 16(1): 17-19.
Citation: Jia Cheng NING, Shu MAO, Ye Di GUAN. Asymmetric Synthesis of α-Substituted-γ-butyrolactone Empolying Prolinol Type of Auxiliaries[J]. Chinese Chemical Letters, 2005, 16(1): 17-19.
Citation: Jia Cheng NING, Shu MAO, Ye Di GUAN. Asymmetric Synthesis of α-Substituted-γ-butyrolactone Empolying Prolinol Type of Auxiliaries[J]. Chinese Chemical Letters, 2005, 16(1): 17-19.
Asymmetric Synthesis of α-Substituted-γ-butyrolactone Empolying Prolinol Type of Auxiliaries
摘要:
Eleven (S)-(-)-bishydrocarbyl-(1-alkanoylpyrrolidin-2-yl)-methanol derivatives of three types were synthesized from L-proline, asymmtrically selective alkylation products were obtained by LDA treatment and alkylation using methyl 2-bromoethyl ether, and three types of chiral α-substituted-γ-butyrolactones were obtained by hydrolyzing the alkylation products, with%e.e.being up to 89 percent.
English
Asymmetric Synthesis of α-Substituted-γ-butyrolactone Empolying Prolinol Type of Auxiliaries
Abstract:
Eleven (S)-(-)-bishydrocarbyl-(1-alkanoylpyrrolidin-2-yl)-methanol derivatives of three types were synthesized from L-proline, asymmtrically selective alkylation products were obtained by LDA treatment and alkylation using methyl 2-bromoethyl ether, and three types of chiral α-substituted-γ-butyrolactones were obtained by hydrolyzing the alkylation products, with%e.e.being up to 89 percent.
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Key words:
- Asymmetric synthesis
- / α-substituted-γ-butyrolactone.
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