引用本文:
Hua YANG, Shao Bing ZHOU, Xian Mo DENG. Synthesis and Characterization of Chitosan-g-poly (D, L-lactic acid) Copolymer[J]. Chinese Chemical Letters,
2005, 16(1): 123-126.
Citation: Hua YANG, Shao Bing ZHOU, Xian Mo DENG. Synthesis and Characterization of Chitosan-g-poly (D, L-lactic acid) Copolymer[J]. Chinese Chemical Letters, 2005, 16(1): 123-126.
Citation: Hua YANG, Shao Bing ZHOU, Xian Mo DENG. Synthesis and Characterization of Chitosan-g-poly (D, L-lactic acid) Copolymer[J]. Chinese Chemical Letters, 2005, 16(1): 123-126.
Synthesis and Characterization of Chitosan-g-poly (D, L-lactic acid) Copolymer
摘要:
Biodegradable chitosan-g-poly (D, L-lactic acid) copolymers were prepared via two methods. (1) The lactide was grafted onto hydroxyl groups of chitosan by using macromolecular initiator sodium of trimethylsilyl-chitosan, (2) poly (D,L-lactic acid) (PLA) with low molecular weight can be linked to the amino group by coupling activated PLA to trimethylsilyl-chitosan. Two graft copolymers had hydrophilic-hydrophobic character and can be applied as carriers for drug delivery.
English
Synthesis and Characterization of Chitosan-g-poly (D, L-lactic acid) Copolymer
Abstract:
Biodegradable chitosan-g-poly (D, L-lactic acid) copolymers were prepared via two methods. (1) The lactide was grafted onto hydroxyl groups of chitosan by using macromolecular initiator sodium of trimethylsilyl-chitosan, (2) poly (D,L-lactic acid) (PLA) with low molecular weight can be linked to the amino group by coupling activated PLA to trimethylsilyl-chitosan. Two graft copolymers had hydrophilic-hydrophobic character and can be applied as carriers for drug delivery.
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Key words:
- Poly (D,L-lactic acid)
- / chitosan
- / graft copolymer
- / coupling
- / macromolecular initiator.
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