引用本文:
Jin Tang DU, Yan Mei LI, Yu Fen ZHAO, Masatoshi NAKAGAWA, Xu Rong QIN, Tadashi NEMOTO, Hiroshi NAKANISHI. MALDI-TOF Mass Spectrometry Study of the Phosphorylated Tau Peptides[J]. Chinese Chemical Letters,
2004, 15(8): 927-930.
Citation: Jin Tang DU, Yan Mei LI, Yu Fen ZHAO, Masatoshi NAKAGAWA, Xu Rong QIN, Tadashi NEMOTO, Hiroshi NAKANISHI. MALDI-TOF Mass Spectrometry Study of the Phosphorylated Tau Peptides[J]. Chinese Chemical Letters, 2004, 15(8): 927-930.
Citation: Jin Tang DU, Yan Mei LI, Yu Fen ZHAO, Masatoshi NAKAGAWA, Xu Rong QIN, Tadashi NEMOTO, Hiroshi NAKANISHI. MALDI-TOF Mass Spectrometry Study of the Phosphorylated Tau Peptides[J]. Chinese Chemical Letters, 2004, 15(8): 927-930.
MALDI-TOF Mass Spectrometry Study of the Phosphorylated Tau Peptides
摘要:
Fragmentation of phosphorylated Tau peptides in matrix assisted laser desorption-/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) has been investigated.According to the post-source decay (PSD) in MALDI-TOF-MS, there are two different patterns of cleavage in phosphopeptides, which can be used to determine the phosphorylated site in peptides.In the synthetic tau peptides, the fragmentation at proline residue occurs strongly and this is useful to determine the structure of tau peptides.
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关键词:
- Mass spectrometry
- / PSD method
- / tau peptide
- / phosphorylation
English
MALDI-TOF Mass Spectrometry Study of the Phosphorylated Tau Peptides
Abstract:
Fragmentation of phosphorylated Tau peptides in matrix assisted laser desorption-/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) has been investigated.According to the post-source decay (PSD) in MALDI-TOF-MS, there are two different patterns of cleavage in phosphopeptides, which can be used to determine the phosphorylated site in peptides.In the synthetic tau peptides, the fragmentation at proline residue occurs strongly and this is useful to determine the structure of tau peptides.
-
Key words:
- Mass spectrometry
- / PSD method
- / tau peptide
- / phosphorylation
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