引用本文:
He Sheng ZHANG, Chuan Fu ZHONG, Xiao Ping BAO. Studies of the Total Synthesis of Epothilone B and D:A Facile Synthesis of C7-C14 and C15-C21 Fragments[J]. Chinese Chemical Letters,
2003, 14(2): 115-117.
Citation: He Sheng ZHANG, Chuan Fu ZHONG, Xiao Ping BAO. Studies of the Total Synthesis of Epothilone B and D:A Facile Synthesis of C7-C14 and C15-C21 Fragments[J]. Chinese Chemical Letters, 2003, 14(2): 115-117.
Citation: He Sheng ZHANG, Chuan Fu ZHONG, Xiao Ping BAO. Studies of the Total Synthesis of Epothilone B and D:A Facile Synthesis of C7-C14 and C15-C21 Fragments[J]. Chinese Chemical Letters, 2003, 14(2): 115-117.
Studies of the Total Synthesis of Epothilone B and D:A Facile Synthesis of C7-C14 and C15-C21 Fragments
摘要:
A mild and highly efficient synthesis of C7-C14 and C15-C21 fragments of epothilone B and D is described in which racemic C7-C14 fragment is prepared from nerol through four steps, and C15-C21 fragment is obtained from 1, 3-dichloroacetone, thioacetamide and propionaldehyde.
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关键词:
- Epothilone B and D
- / anticancer drugs
- / nerol
- / synthesis
English
Studies of the Total Synthesis of Epothilone B and D:A Facile Synthesis of C7-C14 and C15-C21 Fragments
Abstract:
A mild and highly efficient synthesis of C7-C14 and C15-C21 fragments of epothilone B and D is described in which racemic C7-C14 fragment is prepared from nerol through four steps, and C15-C21 fragment is obtained from 1, 3-dichloroacetone, thioacetamide and propionaldehyde.
-
Key words:
- Epothilone B and D
- / anticancer drugs
- / nerol
- / synthesis
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