引用本文:
Yu ZHAO, Wei LU, Xiao Jiang HAO, Jun Chao CAI, Hong YU, Thierry SEVENET, FranÇise GUÉITTE. Synthesis of Cytotoxic Sinapyl Alcohol Derivatives from Ligularia nelumbifolia[J]. Chinese Chemical Letters,
2002, 13(3): 201-204.
Citation: Yu ZHAO, Wei LU, Xiao Jiang HAO, Jun Chao CAI, Hong YU, Thierry SEVENET, FranÇise GUÉITTE. Synthesis of Cytotoxic Sinapyl Alcohol Derivatives from Ligularia nelumbifolia[J]. Chinese Chemical Letters, 2002, 13(3): 201-204.
Citation: Yu ZHAO, Wei LU, Xiao Jiang HAO, Jun Chao CAI, Hong YU, Thierry SEVENET, FranÇise GUÉITTE. Synthesis of Cytotoxic Sinapyl Alcohol Derivatives from Ligularia nelumbifolia[J]. Chinese Chemical Letters, 2002, 13(3): 201-204.
Synthesis of Cytotoxic Sinapyl Alcohol Derivatives from Ligularia nelumbifolia
摘要:
Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivatives 29 and 30 were also synthesized for a SAR investigation. 1 and 2 were also measured on different tumor cell line.
English
Synthesis of Cytotoxic Sinapyl Alcohol Derivatives from Ligularia nelumbifolia
Abstract:
Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivatives 29 and 30 were also synthesized for a SAR investigation. 1 and 2 were also measured on different tumor cell line.
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Key words:
- Natural products
- / cytotoxicity
- / total synthesis
- / SAR
- / pharmaceutical chemistry
- / sinapyl alcohol derivatives
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