Synthesis of Cytotoxic Sinapyl Alcohol Derivatives from Ligularia nelumbifolia

Yu ZHAO Wei LU Xiao Jiang HAO Jun Chao CAI Hong YU Thierry SEVENET FranÇise GUÉITTE

引用本文: Yu ZHAO,  Wei LU,  Xiao Jiang HAO,  Jun Chao CAI,  Hong YU,  Thierry SEVENET,  FranÇise GUÉITTE. Synthesis of Cytotoxic Sinapyl Alcohol Derivatives from Ligularia nelumbifolia[J]. Chinese Chemical Letters, 2002, 13(3): 201-204. shu
Citation:  Yu ZHAO,  Wei LU,  Xiao Jiang HAO,  Jun Chao CAI,  Hong YU,  Thierry SEVENET,  FranÇise GUÉITTE. Synthesis of Cytotoxic Sinapyl Alcohol Derivatives from Ligularia nelumbifolia[J]. Chinese Chemical Letters, 2002, 13(3): 201-204. shu

Synthesis of Cytotoxic Sinapyl Alcohol Derivatives from Ligularia nelumbifolia

  • 基金项目:

    This work is financially supported by the Life Science Special Fund of Chinese Academy of Sciences Supported by the Ministry of Finance (STZ-00-24), the Yunnan Province Foundation of Applied and Basic Research (2000C0072M), the Foundation for Visiting Professor (Y. Z.) from the State Key Laboratory of New Drug Research at SIMM, CAS, the grant from Dean of KIB, CAS, and EGIDE foundation (France).

摘要: Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivatives 29 and 30 were also synthesized for a SAR investigation. 1 and 2 were also measured on different tumor cell line.

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  • 收稿日期:  2001-07-03
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