引用本文:
Rui REN, Pin YANG, Gao Yi HAN. DNA Cleavage by Copper (Ⅱ) Complexes Without added Coreactants[J]. Chinese Chemical Letters,
1999, 10(5): 383-386.
Citation: Rui REN, Pin YANG, Gao Yi HAN. DNA Cleavage by Copper (Ⅱ) Complexes Without added Coreactants[J]. Chinese Chemical Letters, 1999, 10(5): 383-386.
Citation: Rui REN, Pin YANG, Gao Yi HAN. DNA Cleavage by Copper (Ⅱ) Complexes Without added Coreactants[J]. Chinese Chemical Letters, 1999, 10(5): 383-386.
DNA Cleavage by Copper (Ⅱ) Complexes Without added Coreactants
摘要:
The cleavage activity of complexes between copper (Ⅱ)and tour different amino acid or amino acid methyl ester on DNA was tested at physiological pH and temperature. It was found that Cu (Ⅱ)-L-llis and Cu (Ⅱ)-L-llis methyl ester complexes could cleave DNA. The extent of DNN cleavage is largely dependent on the metal ion-to-ligand ratio. The cleavage of double-stranded DNA mediated by Cu (Ⅱ)-L-llis complccs occurs vin a hydrolytic mechanism.
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关键词:
- Copper(Ⅱ)complexes
- / DNA
- / hydrolytic cleavage
English
DNA Cleavage by Copper (Ⅱ) Complexes Without added Coreactants
Abstract:
The cleavage activity of complexes between copper (Ⅱ)and tour different amino acid or amino acid methyl ester on DNA was tested at physiological pH and temperature. It was found that Cu (Ⅱ)-L-llis and Cu (Ⅱ)-L-llis methyl ester complexes could cleave DNA. The extent of DNN cleavage is largely dependent on the metal ion-to-ligand ratio. The cleavage of double-stranded DNA mediated by Cu (Ⅱ)-L-llis complccs occurs vin a hydrolytic mechanism.
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Key words:
- Copper(Ⅱ)complexes
- / DNA
- / hydrolytic cleavage
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