引用本文:
詹艳艳, 杜新贞, 李全民. 在丙酮增敏作用下硝普钠分光光度法测定盐酸吗啉胍[J]. 应用化学,
2009, 26(11): 1357-1361.
Citation: ZHAN Yan-Yan, DU Xin-Zhen, LI Quan-Min. Sodium Nitroprusside Spectrophotometric Determination of Moroxydine Hydrochloride under Sensitization of Acetone[J]. Chinese Journal of Applied Chemistry, 2009, 26(11): 1357-1361.
Citation: ZHAN Yan-Yan, DU Xin-Zhen, LI Quan-Min. Sodium Nitroprusside Spectrophotometric Determination of Moroxydine Hydrochloride under Sensitization of Acetone[J]. Chinese Journal of Applied Chemistry, 2009, 26(11): 1357-1361.
在丙酮增敏作用下硝普钠分光光度法测定盐酸吗啉胍
摘要:
建立了可见分光光度法测定盐酸吗啉胍的新方法。研究表明,当NaOH浓度为0.13 mol/L,在丙酮存在下硝普钠与盐酸吗啉胍反应生成紫色N-亚硝基类化合物,其最大吸收波长为508 nm,表观摩尔吸光系数2.5×103L/(mol.cm)。盐酸吗啉胍浓度在0.38×10-6~3.0×10-4g/mL范围内与吸光度呈现良好线性关系,线性回归方程A=0.022 92+0.012 13c(10-6g/mL),线性相关系数r=0.999 8,检测限(3σ/k)为0.25×10-6g/mL,RSD=0.21%。本方法可用于药物样品和血清中盐酸吗啉胍含量的测定。
English
Sodium Nitroprusside Spectrophotometric Determination of Moroxydine Hydrochloride under Sensitization of Acetone
Abstract:
A new method was proposed for the determination of moroxydine hydrochloride with sodium nitroprusside by spectrophotometry.Colored N-nitrosamine product was formed by moroxydine hydrochloride and sodium nitroprusside in alkaline solution.The liner regression equation is A=0.022 92+0.012 13c(10-6 g/mL) with a correlation coefficient of 0.999 8,and ε was 2.5×103 L/(mol·cm) at 508 nm.Beer's law was well obeyed in a range of moroxydine hydrochloride concentration of 0.38×10-6～3.0×10-4 g/mL,the limit of detection(3σ/k) was 0.25×10-6 g/mL,the RSD was 0.21%.The method was used for the determination of moroxydine hydrochloride in pharmaceutical samples and human serum with satisfactory results.
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Key words:
- sodium nitroprusside
- / moroxydine hydrochloride
- / acetone
- / spectrophotometry
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