引用本文:
张成路, 王利东, 广东, 申洪江, 李元东, 王杨. 3-羰基-10-去甲基-12-甲氧基-13-甲基罗汉松烷的全合成[J]. 应用化学,
2009, 26(11): 1301-1304.
Citation: ZHANG Cheng-Lu, WANG Li-Dong, GUANG Dong, SHEN Hong-Jiang, LI Yuan-Dong, WANG Yang. Total Synthesis of 3-Carbonyl-10-demethyl-12-methoxy-13-methyl-podocarpene[J]. Chinese Journal of Applied Chemistry, 2009, 26(11): 1301-1304.
Citation: ZHANG Cheng-Lu, WANG Li-Dong, GUANG Dong, SHEN Hong-Jiang, LI Yuan-Dong, WANG Yang. Total Synthesis of 3-Carbonyl-10-demethyl-12-methoxy-13-methyl-podocarpene[J]. Chinese Journal of Applied Chemistry, 2009, 26(11): 1301-1304.
3-羰基-10-去甲基-12-甲氧基-13-甲基罗汉松烷的全合成
English
Total Synthesis of 3-Carbonyl-10-demethyl-12-methoxy-13-methyl-podocarpene
Abstract:
A-ring synthon 5 was synthesized from 1,3-cyclohexanedione via methylation and carbonyl protection.C-ring synthon 9 was synthesized from 1-methoxy-2-methylbenzene by means of bromination,the addition of ethylene epoxide and further bromination.Compound 5 reacted with Grignard reagent of 9 followed by cyclozation to afford target molecule 11.All intermediates and target product were confirmed by IR,1H NMR and HRMS.In conclusion,a simple synthetic route has been developed and the target molecule has been successfully synthesized.
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Key words:
- tricyclic diterpene
- / podocapene
- / total synthesis
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