引用本文:
刘新华, 宋宝安, 李波. 新型3,5-二芳基吡唑衍生物的合成与抑菌活性[J]. 应用化学,
2007, 24(7): 835-837.
Citation: LIU Xin-Hua, SONG Bao-An, LI Bo. Synthesis and Fungicidal Activity of Novel 3,5-Diarylpyrazole Derivatives[J]. Chinese Journal of Applied Chemistry, 2007, 24(7): 835-837.
Citation: LIU Xin-Hua, SONG Bao-An, LI Bo. Synthesis and Fungicidal Activity of Novel 3,5-Diarylpyrazole Derivatives[J]. Chinese Journal of Applied Chemistry, 2007, 24(7): 835-837.
新型3,5-二芳基吡唑衍生物的合成与抑菌活性
摘要:
以2-氯苯甲醛与2,4-二氯苯乙酮缩合形成α,β不饱和酮,然后和水合肼关环形成3-(2,4-二氯苯基)-5-(2-氯苯基)吡唑结构骨架,合成了8个未见文献报道的3-(2,4-二氯苯基)-5-(2-氯苯基)-4,5二氢-N-酰基吡唑类衍生物。经过元素分析、红外光谱、核磁共振氢谱测试技术对其结构进行了表征。对新合成的化合物进行了初步生物活性测试结果表明,在化合物的质量浓度为50 mg/L时,化合物3f对水稻纹枯菌和稻瘟病菌的抑菌率分别为55.2%和57.1%。化合物3g对水稻纹枯菌、稻瘟病菌和油菜菌核菌的抑菌率分别为52.3%、60.0%和50.4%。
English
Synthesis and Fungicidal Activity of Novel 3,5-Diarylpyrazole Derivatives
Abstract:
(E)-3-(2-chlorophenyl)-1-(2,4-dichlorophenyl) prop-2-en-1-one was prepared from 2-chlorobenzal-dehyde followed by cyclization with hydrazine monohydrate.Eight new derivatives of 3-(2,4-dichlorophenyl)-5-(2-chlorophenyl)-4,5-dihydro-N-acylpyrazole were synthesized and characterized by elemental analysis,IR and 1H NMR.The experimental results show that the inhibition rates of compound 3f toward H.Oryzae and P.oryzae at 50 mg/L were 55.2% and 57.1%,respectively,and the inhibition rates of compound 3g toward H.Oryzae,P.oryza,and S.Sclerotiorum.at 50 mg/L were 52.3%,60.0% and 50.4%,respectively.
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Key words:
- chlorobenzaldehyde
- / diarylpyrazole
- / synthesis
- / fungicide
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