引用本文:
王朝霞, 闫静, 唐燕辉, 翁小闽, 陈国荣. 固体酸催化合成4-羟基苯基-1'-O-D-吡喃葡萄糖苷[J]. 应用化学,
2007, 24(7): 774-777.
Citation: WANG Zhao-Xia, YAN Jing, TANG Yan-Hui, WENG Xiao-Min, CHEN Guo-Rong. Synthesis of 4-Hydroxyphenyl-1'-O-Dglucopyranoside under Solid Acid Catalysis[J]. Chinese Journal of Applied Chemistry, 2007, 24(7): 774-777.
Citation: WANG Zhao-Xia, YAN Jing, TANG Yan-Hui, WENG Xiao-Min, CHEN Guo-Rong. Synthesis of 4-Hydroxyphenyl-1'-O-Dglucopyranoside under Solid Acid Catalysis[J]. Chinese Journal of Applied Chemistry, 2007, 24(7): 774-777.
固体酸催化合成4-羟基苯基-1'-O-D-吡喃葡萄糖苷
English
Synthesis of 4-Hydroxyphenyl-1'-O-Dglucopyranoside under Solid Acid Catalysis
Abstract:
A new greeen chemosynthesis of 4-hydroxyphenyl-1'-O-D-glucopyrano-side,arbutin and its anomer α-arbutin,is reported.With solid acid,montmorillonite K-10 or 4A molecular sieves as catalysts,benzyl-protected donor (2) or α-trichloroacetimidate (3) was glycosylated with hydroquinone to obtain intermediate (4) in a yield of 86%,and then compound (1) was quantitatively obtained after the deprotection.This method is very benign to environment.The structure of compound (4) was confirmed by IR,MS,1H NMR and elemental analysis,and the data of target compound (1) are the same as those from references.
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Key words:
- solid acid
- / arbutin
- / 4A Molecular sieve
- / montmorillonite K-10
- / glycosylation
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