引用本文:
赵瑾, 卜站伟, 刘洋, 王超杰. 茄呢基氮芥衍生物的合成及生理活性[J]. 应用化学,
2006, 23(5): 514-518.
Citation: ZHAO Jin, BU Zhan-Wei, Liu Yang, WANG Chao-Jie. Synthesis and Biological Activity of New Solanesyl Nitrogen Mustards[J]. Chinese Journal of Applied Chemistry, 2006, 23(5): 514-518.
Citation: ZHAO Jin, BU Zhan-Wei, Liu Yang, WANG Chao-Jie. Synthesis and Biological Activity of New Solanesyl Nitrogen Mustards[J]. Chinese Journal of Applied Chemistry, 2006, 23(5): 514-518.
茄呢基氮芥衍生物的合成及生理活性
English
Synthesis and Biological Activity of New Solanesyl Nitrogen Mustards
Abstract:
Four solanesyl nitrogen mustards were designed and synthesized with solanesol or solanesyl amine as the carrier,maleic acid and phthalic acid as the linkers,and nitrogen mustard as the pharmacophore.Four similar nitrogen mustard derivatives were also prepared with the linear aliphatic alcohols instead of solanesyl derivatives as the carrier to compare their difference.The structures of the compounds were confirmed by IR,1H NMR,MS and elemental analysis.The in vitro anti-tumor activities of these compounds were tested preliminarily on KB,Bel-7402,HCT-8,A549 and MDA cells.The data show that the nitrogen mustard with solanesol as the carrier and maleic acid as the linker inhibits all the five tested cells.
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Key words:
- nitrogen mustard
- / solanesol
- / synthesis
- / biological activity
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