引用本文:
丁丽琴, 王维, 张爱清, 沈长虹. 1,5-二-(3-硝基苯基)-1,4-戊二烯-3-酮的超声合成[J]. 应用化学,
2006, 23(10): 1090-1093.
Citation: DING Li-Qin, WANG Wei, ZHANG Ai-Qing, SHEN Chang-Hong. Synthesis of 1,5-Bis-(3-nitrophenyl)-1,4-pentadien-3-one under Ultrasound in the Presence of Anhydrous K2CO3[J]. Chinese Journal of Applied Chemistry, 2006, 23(10): 1090-1093.
Citation: DING Li-Qin, WANG Wei, ZHANG Ai-Qing, SHEN Chang-Hong. Synthesis of 1,5-Bis-(3-nitrophenyl)-1,4-pentadien-3-one under Ultrasound in the Presence of Anhydrous K2CO3[J]. Chinese Journal of Applied Chemistry, 2006, 23(10): 1090-1093.
1,5-二-(3-硝基苯基)-1,4-戊二烯-3-酮的超声合成
摘要:
以无水K2CO3为催化剂,在超声辐射下,由硝基苯甲醛和丙酮经Claisen-Schmidt缩合反应制得1,5-二-(3-硝基苯基)-1,4-戊二烯-3-酮,并讨论了影响产物收率的因素。结果表明,最佳反应条件为反应物硝基苯甲醛与丙酮摩尔比为2,甲醇用量为3 mL,催化剂无水K2CO3与间硝基苯甲醛的摩尔比为0.4,在33℃下用450 W超声辐射,反应20 min,收率达88%以上,具有反应时间短,条件温和,操作简便和收率高等优点。
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关键词:
- 二-(硝基苯基)-戊二烯-酮
- / 合成
- / 超声
- / 催化
English
Synthesis of 1,5-Bis-(3-nitrophenyl)-1,4-pentadien-3-one under Ultrasound in the Presence of Anhydrous K2CO3
Abstract:
The synthesis of 1,5-bis-(3-nitrophenyl)-1,4-pentadien-3-one though the Claisen-Schmidt condensation between 3-nitrobenzaldehyde and acetone was performed in methanol under ultrasound in the presence of anhydrous K2CO3.The results show that the best reaction conditions are that the molar ratio of 3-nitrobenzaldehyde vs acetone is 2,amount of methanol 3 mL,the molar ratio of anhydrous K2CO3 vs 3-nitrobenzaldehyde 0.4,the reaction is performed at 33℃ for 20 min in a 450 W ultrasound cleaner,and the yield is over 88%.Compared with previous methods in the literature,the present procedure has the advaotages of shorter reaction time,easier work-up,milder conditions and higher yields.
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Key words:
- bis-(nitrophenyl)-pentadien-one
- / synthesis
- / ultrasound
- / catalyst
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