引用本文:
邴乃慈, 许振良, 杨座国, 王学军, 冯建立. 热聚合制备左氧氟沙星分子印迹聚合物的分子识别特性[J]. 应用化学,
2006, 23(10): 1085-1089.
Citation: BING Na-Ci, XU Zhen-Liang, YANG Zuo-Guo, WANG Xue-Jun, FENG Jian-Li. Characteristics of Levofloxacin Imprinted Polymers Prepared via Thermal Polymerization Method[J]. Chinese Journal of Applied Chemistry, 2006, 23(10): 1085-1089.
Citation: BING Na-Ci, XU Zhen-Liang, YANG Zuo-Guo, WANG Xue-Jun, FENG Jian-Li. Characteristics of Levofloxacin Imprinted Polymers Prepared via Thermal Polymerization Method[J]. Chinese Journal of Applied Chemistry, 2006, 23(10): 1085-1089.
热聚合制备左氧氟沙星分子印迹聚合物的分子识别特性
摘要:
以左氧氟沙星(LVFX)为模板分子,α-甲基丙烯酸(MAA)为功能单体,制备了能选择性识别LVFX的分子印迹聚合物(MIPs)。紫外光谱和红外光谱分析结果表明,该MIPs通过氢键和离子键对LVFX进行识别;Scatchard分析显示,MAA与LVFX在自组装过程中形成了2类结合位点,最大表观结合容量Qmax分别为9.76和25.75 μmol/g,在10 min中内基本完成了对LVFX的选择性吸附;MIPs热力学研究表明,吸附过程是自发进行的,ΔΔH=-1.18 kJ/mol和ΔΔS=-0.27 J/(mol·K)。
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关键词:
- 左氧氟沙星
- / 分子印迹聚合物
- / Scatchard分析
- / 热力学
English
Characteristics of Levofloxacin Imprinted Polymers Prepared via Thermal Polymerization Method
Abstract:
Molecularly imprinted polymers(MIPs) were synthesized via thermal polymerization method with levofloxacin(LVFX) as template and methyacrylic acid as functional monomer.The UV and IR spectra indicated that the MIPs could recognize LVFX molecule through hydrogen-bond and ionic-bond interactions.Scatchard analysis showed that two kinds of recognition sites were formed,and the maximum apparent binding capacities were 9.76 μmol/g and 25.75 μmol/g,respectively.The selective adsorption of LVFX on MIPs could be completed in 10 min.On the basis of isothermal binding thermodynamics,the absorption to the template was spontaneous,and ΔΔH=-1.18 kJ/mol and ΔΔS=-0.27 J/(mol·K).
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Key words:
- levofloxacin(LVFX)
- / molecularly imprinted polymer
- / scatchard analysis
- / thermodynamics
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