引用本文:
谢安建, 沈玉华, 黄方志, 庄永龙, 宋庆平. 胆红素/HDEHP反相微乳液的制备及应用[J]. 应用化学,
2003, 20(9): 823-828.
Citation: XIE An-Jian, SHEN Yu-Hua, HUANG Fang-Zhi, ZHUANG Yong-Long, SONG Qing-Ping. Preparation and Application of the Reversed Microemulsion Containing Bilirubin/HDEHP[J]. Chinese Journal of Applied Chemistry, 2003, 20(9): 823-828.
Citation: XIE An-Jian, SHEN Yu-Hua, HUANG Fang-Zhi, ZHUANG Yong-Long, SONG Qing-Ping. Preparation and Application of the Reversed Microemulsion Containing Bilirubin/HDEHP[J]. Chinese Journal of Applied Chemistry, 2003, 20(9): 823-828.
胆红素/HDEHP反相微乳液的制备及应用
摘要:
制备了部分皂化的含胆红素(H2BR)/二(2乙基已基)磷酸酯(HDEHP)/氯仿/苯/氨水的反相微乳液,并通过透射电镜、电导率仪和动态激光光散射仪等对所制备的微乳液进行了表征。结果表明,苯和氯仿的体积比为7:3的混合溶液为该微乳液形成的最佳有机溶剂,1.00mol/L的氨水为最有效皂化剂;形成微乳液的H2BR和HDEHP的摩尔比随2个表面活性剂总浓度的增加而减小;H2BR量的多少对微乳液内增溶的水量影响较大。微乳液内的水滴直径在60~120nm范围内,以此微乳液作为细胞膜模拟体系,制备了含CaCl2/H2BR/HDEHP/氯仿/苯/氨水的新微乳液,并进一步诱导和调控了胆红素钙的形成,发生了类似生物体内的矿化过程。
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关键词:
- 反相微乳液
- / 胆红素
- / 二(乙基已基)磷酸酯
- / 胆红素钙
- / 生物矿化
English
Preparation and Application of the Reversed Microemulsion Containing Bilirubin/HDEHP
Abstract:
Bilirubin(H2BR) and di-(2-ethylhexyl) phosphoric acid(HDEHP) were dissolved in chloroform/benzene mixture and partially saponified by ammonia to prepare reversed microemulsions which were characterized by TEM, conductometry and dynamic laser-scattering. The results showed that the mixture of benzene and chloroform in volume ratio of 7:3 was an optimal solvent and ammonia with concentration of 1.00 mol/L was the best saponifier for the formation of microemulsions. The molar ratio of H2BR to HDEHP decreased with the increase in the total concentration of surfactants. The content of H2BR affected greatly the amount of water in microemulsions. The diameter of water pool in microemulsions ranged from 60 nm to 120 nm, which were used to simulate a cell membrane and to produce a new reversed microemulsions containing CaCl2/H2BR/HDEHP. Calcium bilirubinate could be induced and controlled by both surfactants in the system, similar to that of biomineralization process in organism.
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Key words:
- reversed microemulsion
- / bilirubin
- / HDEHP
- / calcium bilirubinate
- / biomineralization
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