引用本文:
李万华, 路军, 马怀让. 三氯化镧催化一锅法合成3,4-二氢嘧啶-2-酮[J]. 应用化学,
2001, 18(7): 566-568.
Citation: LI Wan-Hu, LU Jun, Ma Huai-Rang. Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Lanthanum Chloride as a Catalyst[J]. Chinese Journal of Applied Chemistry, 2001, 18(7): 566-568.
Citation: LI Wan-Hu, LU Jun, Ma Huai-Rang. Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Lanthanum Chloride as a Catalyst[J]. Chinese Journal of Applied Chemistry, 2001, 18(7): 566-568.
三氯化镧催化一锅法合成3,4-二氢嘧啶-2-酮
摘要:
Biginelli于1893年首次报道了乙酰乙酸乙酯、芳香醛和脲在浓盐酸催化下缩合得到3, 4-二氢嘧啶-2-酮衍生物, 这一合成方法被称为Biginelli反应[1].
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关键词:
- 二氢嘧啶酮
- / Big inelli反应
- / 三氯化镧
- / 合成
English
Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Lanthanum Chloride as a Catalyst
Abstract:
An efficient one-pot synthesis method for 3,4-dihydropyrimidinones using lanthanum chloride heptahydrate as a catalyst by the reaction of aldehyde, U-keto ester and urea(in molar ratio 1:1:1.5) in ethanol is described.The method is simple and affords product in good yield(80%~90%).
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Key words:
- dihydropyrimidinone
- / Biginelli reaction
- / lanthanum heptahydrate
- / synthesis
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