引用本文:
张林, 谢如刚. 氘代苯乙酮-d8的合成与还原反应[J]. 应用化学,
1999, 16(1): 115-116.
Citation: Zhang Lin, Xie Rugang. Synthesis and Reduction of Deuterated Acetophenone-d8[J]. Chinese Journal of Applied Chemistry, 1999, 16(1): 115-116.
Citation: Zhang Lin, Xie Rugang. Synthesis and Reduction of Deuterated Acetophenone-d8[J]. Chinese Journal of Applied Chemistry, 1999, 16(1): 115-116.
氘代苯乙酮-d8的合成与还原反应
摘要:
氘代苯乙酮-d8及其还原产物氘代α-苯乙醇-d10是合成众多氘标记化合物及全氘代化合物的重要中间体.以氘代苯-d6和氘代醋酸-d4为原料制得氘代苯乙酮-d8,经LiAlD4还原可得氘代α-苯乙醇-d10[1].
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关键词:
- 氘代苯乙酮-d8
- / 合成
- / 镍-铝合金
- / 还原
- / 氘代α-苯乙醇-d10
English
Synthesis and Reduction of Deuterated Acetophenone-d8
Abstract:
Deuterated acetophenone-d8(C6D5-COCD3) was prepared from perdeutero-benzene (C6D6)and perdeutero-acetic acid in high yield and high deuterium isotopic content(about 86% and 99.3% respectively). C6D5-COCD3 was then reduced with nickel-aluminum (Ni-Al) alloy in 12%~18% NaOD-D2O solution to give corresponding deuterated α-phenylethanol-d10(C6D5-CDODCD3), the yield and deuterium isotopic content were 85.2% and 99.2%.
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