引用本文:
胡艾希, 范国枝, 赵海涛, 王桂英. (1'S,4R,5R)-2-(1'-溴乙基)-2-(5-溴-6-甲氧基-2-萘基)-1,3-二氧戊环-4,5-二羧酸的不对称合成[J]. 应用化学,
1999, 16(1): 110-112.
Citation: Hu Aixi, Fan Guozhi, Zhao Haitao, Wang Guiying. Asymmetric Synthesis of (1'S, 4R, 5R)-2-(1'-Bromoethyl)-2-(5-bromo-6-methoxy-2-naphthyl)-1, 3-dioxolane-4, 5-dicarboxylic Acid[J]. Chinese Journal of Applied Chemistry, 1999, 16(1): 110-112.
Citation: Hu Aixi, Fan Guozhi, Zhao Haitao, Wang Guiying. Asymmetric Synthesis of (1'S, 4R, 5R)-2-(1'-Bromoethyl)-2-(5-bromo-6-methoxy-2-naphthyl)-1, 3-dioxolane-4, 5-dicarboxylic Acid[J]. Chinese Journal of Applied Chemistry, 1999, 16(1): 110-112.
(1'S,4R,5R)-2-(1'-溴乙基)-2-(5-溴-6-甲氧基-2-萘基)-1,3-二氧戊环-4,5-二羧酸的不对称合成
摘要:
萘普生[(S)-2-(6-甲氧基-2-萘基)丙酸]是一种非常重要的非麻醉性消炎镇痛药.周宏英等[1]报道了用手性膦配体DDPPI对2-(6-甲氧基-2-萘基)乙醇进行不对称羰基化反应合成了萘普生甲酯.
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关键词:
- 溴乙基溴甲氧基萘基二氧戊环二羧酸
- / 酒石酸二甲酯
- / 不对称合成
English
Asymmetric Synthesis of (1'S, 4R, 5R)-2-(1'-Bromoethyl)-2-(5-bromo-6-methoxy-2-naphthyl)-1, 3-dioxolane-4, 5-dicarboxylic Acid
Abstract:
Title compound was synthesized with total yield of 80% by acetalization, asymmetric bromination, hydrolysis of 6-methoxy-2-propionylnaphthalene, using (2R, 3R)-dimethyl tartrate as a chiral auxiliary.
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